5-Methyl-2-pyrrolidone → HCID 71252669, compound

HRID 2412129Notes

Reaction equation

HRID 2412129 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([CH3:24])=[CH:22][C:21]([CH3:25])=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[C:6]([CH:9]=1)[C:7]#[N:8].[CH3:26][CH:27]1[NH:31][C:30](=[O:32])[CH2:29][CH2:28]1>>[CH3:24][C:23]1[C:18]([N:15]2[CH2:16][CH2:17][N:12]([C:10]([C:5]3[CH:4]=[CH:3][C:2]([N:31]4[C:30](=[O:32])[CH2:29][CH2:28][CH:27]4[CH3:26])=[CH:9][C:6]=3[C:7]#[N:8])=[O:11])[CH2:13][CH2:14]2)=[N:19][CH:20]=[C:21]([CH3:25])[CH:22]=1

Participants

3

Reactant 2

HCID 660555-Methyl-2-pyrrolidoneHCID 584846285-Bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile

Product 1

HCID 71252669HCID 71252669, compoundYield 92.3%

Procedure

Using 5-bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (1 g) described in Preparation Example 187 and 5-methylpyrrolidin-2-one (372 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (965 mg) was obtained.

Sources & evidence

ORD record
ord-923fe5664bbf4b1f9cb671aa1cf4f08c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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