1-Methylpiperazine → HCID 71252101, compound

HRID 2412133Notes

Reaction equation

C(O[C:6]([N:8]([C:40](OC(C)(C)C)=O)[C:9](=[O:39])[C:10]1[CH:15]=[C:14]([N:16]2[C:20](=[O:21])[CH2:19][CH2:18][CH:17]2C)[CH:13]=[CH:12][C:11]=1[C:23]([N:25]1[CH2:30][CH2:29][N:28]([C:31]2[C:36]([CH3:37])=[CH:35][C:34]([CH3:38])=[CH:33][N:32]=2)[CH2:27][CH2:26]1)=[O:24])=O)(C)(C)C.[CH3:47][N:48]1[CH2:53]CNC[CH2:49]1>>[CH3:37][C:36]1[C:31]([N:28]2[CH2:27][CH2:26][N:25]([C:23]([C:11]3[CH:12]=[CH:13][C:14]([N:16]4[CH2:17][CH2:18][CH2:19][C:20]4=[O:21])=[CH:15][C:10]=3[C:9]([N:8]3[CH2:6][CH2:49][N:48]([CH3:53])[CH2:47][CH2:40]3)=[O:39])=[O:24])[CH2:30][CH2:29]2)=[N:32][CH:33]=[C:34]([CH3:38])[CH:35]=1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 71252354HCID 71252354, compound

Product 1

HCID 71252101HCID 71252101, compoundYield 58.3%

Procedure

Using N,N-di-tert-butyloxycarbonyl-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-5-(2-methyl-5-oxopyrrolidin-1-yl)benzamide (80 mg) described in Example 837 and 1-methylpiperazine (52 mg) and by the reaction and treatment in the same manner as in Example 770, the title compound (37 mg) was obtained.

Sources & evidence

ORD record: ord-d58d0c21e1bb4698812713f670a66f28
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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