Pyridine → HCID 57006373, compound

HRID 2412314Notes

Reaction equation

HRID 2412314 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][OH:6])[CH3:2].N1C=CC=CC=1.[F:13][CH:14]([CH2:16][C:17](Cl)=[S:18])[F:15]>ClCCl>[F:13][CH:14]([CH2:16][C:17]([O:6][CH2:5][CH2:4][O:3][CH2:1][CH3:2])=[S:18])[F:15]

Participants

5

Reactant 3

HCID 1049PyridineHCID 8076Glycol monoethyl etherHCID 19880176HCID 19880176, compound

Product 1

HCID 57006373HCID 57006373, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred and ice cooled solution of 2-ethoxyethanol (1.2 equivalents) and pyridine (1.3 equivalents) in dichloromethane (5 parts by weight) is dropwise added difluoromethylthioacetyl chloride. After stirring for 4 hours, the mixture is washed with saline, dried and concentrated. The residual liquid is distilled to give oily 2-ethoxyethyl difluoromethylthioacetate. Yield: 60%.

Workup

  1. stirringAfter stirring for 4 hours
  2. washthe mixture is washed with saline
  3. customdried
  4. concentrationconcentrated
  5. distillationThe residual liquid is distilled

Sources & evidence

ORD record
ord-6d20ccfafc354f08b513e75b5df9c7c2
Source dataset
uspto-grants-1985_01
Patent number
US04491547

Reaction notes

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