Pyridine → HCID 57006373, compound

Participants

Reaction Steps

To a stirred and ice cooled solution of 2-ethoxyethanol (1.2 equivalents) and pyridine (1.3 equivalents) in dichloromethane (5 parts by weight) is dropwise added difluoromethylthioacetyl chloride. After stirring for 4 hours, the mixture is washed with saline, dried and concentrated. The residual liquid is distilled to give oily 2-ethoxyethyl difluoromethylthioacetate. Yield: 60%.

Provenance & Evidence