HCID 131714074, compound → H-Pro-Trp-Met-NH2

HRID 2412323Notes

Reaction equation

HRID 2412323 reaction equation
[N:1]1(C(OC(C)(C)C)=O)[CH2:30][CH2:29][CH2:28][C@H:2]1[C:3]([NH:5][C@H:6]([C:17]([NH:19][C@H:20]([C:25]([NH2:27])=[O:26])[CH2:21][CH2:22][S:23][CH3:24])=[O:18])[CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)=[O:4]>C(O)C>[NH:1]1[CH2:30][CH2:29][CH2:28][C@H:2]1[C:3]([NH:5][C@H:6]([C:17]([NH:19][C@H:20]([C:25]([NH2:27])=[O:26])[CH2:21][CH2:22][S:23][CH3:24])=[O:18])[CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)=[O:4]

Participants

3

Reactant 1

HCID 131714074HCID 131714074, compound

Product 1

HCID 13306573H-Pro-Trp-Met-NH2Yield 86.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Starting from 3.722 g (7 mmol) of Boc-Pro-Trp-Met-NH2 (VI) and operating as in Step 2 of Example 1, 2.621 g (80% yield) of VII were obtained from absolute ethyl alcohol; [α]D20 =-23.0° (c=1 MeOH); RfC 0.41; E1.2 0.76.

Sources & evidence

ORD record
ord-7747a47ad94a47669a06f234635562cd
Source dataset
uspto-grants-1985_01
Patent number
US04491541

Reaction notes

Loading…