2-Amino-4,6-dimethyl pyrimidine → HCID 13135277, compound

HRID 2412373Notes

Reaction equation

HRID 2412373 reaction equation
[Cl:1][CH:2]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH2:3][S:4]([N:7]=[C:8]=[O:9])(=[O:6])=[O:5].[NH2:20][C:21]1[N:26]=[C:25]([CH3:27])[CH:24]=[C:23]([CH3:28])[N:22]=1>ClCCl>[CH3:28][C:23]1[CH:24]=[C:25]([CH3:27])[N:26]=[C:21]([NH:20][C:8]([NH:7][S:4]([CH:3]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH:2]2[Cl:1])(=[O:5])=[O:6])=[O:9])[N:22]=1

Participants

4

Reactant 2

HCID 130212-Amino-4,6-dimethyl pyrimidineHCID 20432127HCID 20432127, compound

Product 1

HCID 13135277HCID 13135277, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

15.4 g (0.05 mole) of 2-chlorododecylsulfonyl isocyanate in 100 ml of dichloromethane were initially introduced and 6.2 g (0.05 mole) of 2-amino-4,6-dimethylpyrimidine were added in portions at 0° C. The mixture was initially stirred at 0° C. for 2 hours and then at room temperature for 18 hours and was then worked up in analogy to Example 5. 15.2 g (71% of theory) of N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-2-chlorocyclododecylsulfonamide were obtained (pale yellow solid material, melting point 84° C.).

Workup

  1. waitat room temperature for 18 hours

Sources & evidence

ORD record
ord-61524f3ad845459b8f7b4e33177ae34e
Source dataset
uspto-grants-1985_01
Patent number
US04492598

Reaction notes

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