2-Amino-4,6-dimethyl pyrimidine → HCID 20432160, compound

HRID 2412374Notes

Reaction equation

HRID 2412374 reaction equation
[Cl:1][CH:2]1[CH:7]2[CH2:8][CH:4]([CH2:5][CH2:6]2)[CH:3]1[S:9]([N:12]=[C:13]=[O:14])(=[O:11])=[O:10].[NH2:15][C:16]1[N:21]=[C:20]([CH3:22])[CH:19]=[C:18]([CH3:23])[N:17]=1>ClCCl>[CH3:23][C:18]1[CH:19]=[C:20]([CH3:22])[N:21]=[C:16]([NH:15][C:13]([NH:12][S:9]([CH:3]2[CH:2]([Cl:1])[CH:7]3[CH2:8][CH:4]2[CH2:5][CH2:6]3)(=[O:10])=[O:11])=[O:14])[N:17]=1

Participants

4

Reactant 2

HCID 130212-Amino-4,6-dimethyl pyrimidineHCID 20432162HCID 20432162, compound

Product 1

HCID 20432160HCID 20432160, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

14.1 g (0.06 mole) of 3-chlorobicyclo[2.2.1]hept-2-ylsulfonyl isocyanate in 100 ml of dichloromethane were initially introduced and 7.4 g (0.06 mole) of 2-amino-4,6-dimethylpyrimidine were added in portions at 0° C. The mixture was initially stirred at 0° C. for 2 hours and then at room temperature for 18 hours and then worked up in analogy to Example 5. 14.1 g (66% of theory) of N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-3-chlorobicyclo[2.2.1]hept-2-ylsulfonamide were obtained (viscous oil).

Workup

  1. waitat room temperature for 18 hours

Sources & evidence

ORD record
ord-995e79b62cd0415eb43894b53c4e9400
Source dataset
uspto-grants-1985_01
Patent number
US04492598

Reaction notes

Loading…