HCID 54331231, compound → HCID 54331967, compound

HRID 2412433Notes

Reaction equation

HRID 2412433 reaction equation
[CH3:1][N:2]([CH:4]=[N:5][S:6]([C:9]1[C:10]([O:22][C:23]2[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=2)=[C:11]([N+:19]([O-])=O)[CH:12]=[C:13]([CH:18]=1)[C:14]([O:16][CH3:17])=[O:15])(=[O:8])=[O:7])[CH3:3]>CN(C)C=O.[Ni]>[NH2:19][C:11]1[CH:12]=[C:13]([CH:18]=[C:9]([S:6]([N:5]=[CH:4][N:2]([CH3:1])[CH3:3])(=[O:7])=[O:8])[C:10]=1[O:22][C:23]1[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=1)[C:14]([O:16][CH3:17])=[O:15]

Participants

4

Reactant 1

HCID 54331231HCID 54331231, compound

Product 1

HCID 54331967HCID 54331967, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 6228DimethylformamideSolvent

Procedure

150 g of methyl 5-dimethylaminomethyleneaminosulfonyl-3-nitro-4-(3-pyridyloxy)-benzoate are hydrogenated in dimethylformamide at 50° C. and under 50 atmospheres for 15 hours in an autoclave, using Raney nickel as the catalyst. The reaction mixture is then filtered, the filtrate is concentrated and the residue is recrystallized from dimethylformamide/CH3OH.

Workup

  1. filtrationThe reaction mixture is then filtered
  2. concentrationthe filtrate is concentrated
  3. customthe residue is recrystallized from dimethylformamide/CH3OH

Sources & evidence

ORD record
ord-d3798876a77e4eb39ed09c2e6dbeb005
Source dataset
uspto-grants-1985_01
Patent number
US04492710

Reaction notes

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