2-Propanone, 1-bromo-3-(4-nitrophenyl)- → HCID 13093759, compound

HRID 2412467Notes

Reaction equation

HRID 2412467 reaction equation
Br[CH2:2][C:3]([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1)=[O:4].[C:15]1(=[O:25])[NH:19][C:18](=[O:20])[C:17]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]12.[K]>C1(C)C=CC=CC=1>[C:15]1(=[O:25])[N:19]([CH2:2][C:3]([CH2:5][C:6]2[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=2)=[O:4])[C:18](=[O:20])[C:17]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]12

Participants

4

Reactant 2

HCID 122323022-Propanone, 1-bromo-3-(4-nitrophenyl)-HCID 24194345Phthalimide potassium salt

Product 1

HCID 13093759HCID 13093759, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 1-bromo-3-(4-nitrophenyl)acetone and potassium phthalimide (7.2 g.) in toluene (100 ml.) was heated under reflux with stirring for 4 hours. The mixture was filtered, the filtrate evaporated. The residue was purified by chromatography on silica gel using CH2Cl2 as eluant to give 1-phthalimido-3-(4-nitrophenyl)acetone, m.p. 184°.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux
  3. filtrationThe mixture was filtered
  4. customthe filtrate evaporated
  5. customThe residue was purified by chromatography on silica gel

Sources & evidence

ORD record
ord-c47d263c92f646cfbea3b935dec90581
Source dataset
uspto-grants-1985_01
Patent number
US04492692

Reaction notes

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