HRID2412477

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12300404

Acetyl isocyanate

C3H3NO2

结构：O=C(Nc1ccccc1)OCCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(F)n1

HCID20432451

未命名化合物

结构：OCCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(F)n1

HCID20432455

未命名化合物

PRODUCTS

生成物

结构：CC(=O)NC(=O)OCCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(F)n1

HCID20432407

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

A solution of 2-fluoro-4-(3-hydroxypropyl)-1-triphenylmethylimidazole in pyridine was treated with acetyl isocyanate at 85°. Work up as for the starting material of Example 11 gave 4-(3-acetylcarbamoyloxypropyl)-2-fluoro-1-triphenylmethylimidazole, having the following n.m.r. spectrum in d6DMSO: 1.82 (m, 2H); 2.12 (s, 3H); 2.45 (t, 2H) 4.05 (t, 2H); 6.28 (s, 1H); 7.0-7.5 (m, 15H); 10.12 (br, 1H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8d8b2b09640c4caea5db66a7a5fdc805
来源数据集: uspto-grants-1985_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04492692
来源说明: uspto-grants-1985_01

反应 SMILES

[F:1][C:2]1[N:3]([C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:4]=[C:5]([CH2:7][CH2:8][CH2:9][OH:10])[N:6]=1.[C:30]([N:33]=[C:34]=[O:35])(=[O:32])[CH3:31].FC1N(C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)C=C(CCCOC(=O)NC2C=CC=CC=2)N=1>N1C=CC=CC=1>[C:30]([NH:33][C:34]([O:10][CH2:9][CH2:8][CH2:7][C:5]1[N:6]=[C:2]([F:1])[N:3]([C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:4]=1)=[O:35])(=[O:32])[CH3:31]