HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl isocyanate → 4-(3-Acetylcarbamoyloxypropyl)-2-fluoro-1-triphenylmethylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl isocyanate | HCID 12300404 | — |
| Reactant | 2-Fluoro-4-(3-phenylcarbamoyloxypropyl)-1-triphenylmethylimidazole | HCID 20432451 | — |
| Reactant | 2-Fluoro-4-(3-hydroxypropyl)-1-triphenylmethylimidazole | HCID 20432455 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 4-(3-Acetylcarbamoyloxypropyl)-2-fluoro-1-triphenylmethylimidazole | HCID 20432407 | — |
Reaction Steps
A solution of 2-fluoro-4-(3-hydroxypropyl)-1-triphenylmethylimidazole in pyridine was treated with acetyl isocyanate at 85°. Work up as for the starting material of Example 11 gave 4-(3-acetylcarbamoyloxypropyl)-2-fluoro-1-triphenylmethylimidazole, having the following n.m.r. spectrum in d6DMSO: 1.82 (m, 2H); 2.12 (s, 3H); 2.45 (t, 2H) 4.05 (t, 2H); 6.28 (s, 1H); 7.0-7.5 (m, 15H); 10.12 (br, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04492692 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-8d8b2b09640c4caea5db66a7a5fdc805 |
| Source note | uspto-grants-1985_01 |