HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Isocyanatopyridine → 2-Fluoro-4-[3-(pyrid-3-yl)carbamoyloxypropyl]-1-triphenylmethylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Isocyanatopyridine | HCID 2760493 | — |
| Reactant | 3-(1H-imidazol-2-yl)propan-1-ol | HCID 17925287 | — |
| Reactant | 4-(3-Acetylcarbamoyloxypropyl)-2-fluoro-1-triphenylmethylimidazole | HCID 20432407 | — |
| Product | 2-Fluoro-4-[3-(pyrid-3-yl)carbamoyloxypropyl]-1-triphenylmethylimidazole | HCID 20432417 | — |
Reaction Steps
A solution of the hydroxypropylimidazole was treated with 3-pyridylisocyanate as for the starting material of Example 12, to give 2-fluoro-4-[3-(pyrid-3-yl)carbamoyloxypropyl]-1-triphenylmethylimidazole having the following n.m.r. spectrum in CDCl3 : 1.97 (m, 2H); 2.5 (t, 2H); 4.16 (t, 2H); 6.25 (s, 1H); 6.9 (br s, 1H); 7.0-7.5 (m, 15H); 7.7-8.6 (m, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04492692 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-b8e87ebb386e4a78840c9a8967a7afd9 |
| Source note | uspto-grants-1985_01 |