HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethyl-2,3-dioxopiperazinecarbonyl chloride → 4-[3-(2,3-Dioxo-4-ethylpiperazine-1-carbonylamino)propyl]-2-fluoro-1-triphenylmethylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethyl-2,3-dioxopiperazinecarbonyl chloride | HCID 108813 | — |
| Reactant | 4-(3-Aminopropyl)-2-fluoro-1-triphenylmethylimidazole | HCID 20432314 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[3-(2,3-Dioxo-4-ethylpiperazine-1-carbonylamino)propyl]-2-fluoro-1-triphenylmethylimidazole | HCID 20432376 | — |
Reaction Steps
Crude 4-(3-aminopropyl)-2-fluoro-1-triphenylmethylimidazole was dissolved in CH2Cl2 and treated with 4-dimethylaminopyridine and a solution of 1-chlorocarbonyl-4-ethylpiperazine-2,3-dione in CH2Cl2. Work-up by chromatography gave 4-[3-(2,3-dioxo-4-ethylpiperazine-1-carbonylamino)propyl]-2-fluoro-1-triphenylmethylimidazole, having the following n.m.r. spectrum in CDCl3 : 1.25 (t, 3H); 1.85 (quintet, 2H); 2.25-3.7 (m, 6H); 4.05 (q, 2H); 6.25 (s, 1H); 7.05-7.5 (m, 15H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04492692 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-1e671b23657547fda9e6b13a21b10116 |
| Source note | uspto-grants-1985_01 |