HRID2412484

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID108813

4-Ethyl-2,3-dioxopiperazine-1-carbonyl chloride

C7H9ClN2O3

结构：NCCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(F)n1

HCID20432314

未命名化合物

PRODUCTS

生成物

结构：CCN1CCN(C(=O)NCCCc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c(F)n2)C(=O)C1=O

HCID20432376

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

溶剂HCID6344

Dichloromethane

CH2Cl2

2 次

PROCEDURE

实验过程

Crude 4-(3-aminopropyl)-2-fluoro-1-triphenylmethylimidazole was dissolved in CH2Cl2 and treated with 4-dimethylaminopyridine and a solution of 1-chlorocarbonyl-4-ethylpiperazine-2,3-dione in CH2Cl2. Work-up by chromatography gave 4-[3-(2,3-dioxo-4-ethylpiperazine-1-carbonylamino)propyl]-2-fluoro-1-triphenylmethylimidazole, having the following n.m.r. spectrum in CDCl3 : 1.25 (t, 3H); 1.85 (quintet, 2H); 2.25-3.7 (m, 6H); 4.05 (q, 2H); 6.25 (s, 1H); 7.05-7.5 (m, 15H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1e671b23657547fda9e6b13a21b10116
来源数据集: uspto-grants-1985_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04492692
来源说明: uspto-grants-1985_01

反应 SMILES

[NH2:1][CH2:2][CH2:3][CH2:4][C:5]1[N:6]=[C:7]([F:29])[N:8]([C:10]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:9]=1.Cl[C:31]([N:33]1[CH2:38][CH2:37][N:36]([CH2:39][CH3:40])[C:35](=[O:41])[C:34]1=[O:42])=[O:32]>C(Cl)Cl.CN(C)C1C=CN=CC=1>[O:42]=[C:34]1[C:35](=[O:41])[N:36]([CH2:39][CH3:40])[CH2:37][CH2:38][N:33]1[C:31]([NH:1][CH2:2][CH2:3][CH2:4][C:5]1[N:6]=[C:7]([F:29])[N:8]([C:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:9]=1)=[O:32]