Pyridine-4-carbonyl chloride → HCID 20432362, compound

HRID 2412485Notes

Reaction equation

HRID 2412485 reaction equation
[C:1]([NH:4][CH2:5][CH2:6][C:7]1[N:8]=[C:9]([F:31])[N:10]([C:12]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:11]=1)(=[O:3])[CH3:2].C(Cl)(=O)C1[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=1>>[F:31][C:9]1[N:10]([C:12]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:11]=[C:7]([CH2:6][CH2:5][NH:4][C:1](=[O:3])[C:2]2[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=2)[N:8]=1

Participants

3

Reactant 2

HCID 417436Pyridine-4-carbonyl chlorideHCID 20432415HCID 20432415, compound

Product 1

HCID 20432362HCID 20432362, compound

Procedure

Use of the same technique as for the starting material of Example 29, but replacing acetyl chloride with isonicotinoyl chloride gave 2-fluoro-4-(2-isonicotinoylaminoethyl)-1-triphenylmethylimidazole, having the following n.m.r. spectrum in CDCl3 : 2.7 (t, 2H); 3.71 (q, 2H); 6.35 (s, 1H); 7.0-7.5 (m, 15H); 7.65 (q, 2H); 8.72 (q, 2H).

Sources & evidence

ORD record
ord-a2d4dab500be43c78d8eeb46ae3e978e
Source dataset
uspto-grants-1985_01
Patent number
US04492692

Reaction notes

Loading…