3-Methyl-5-isoxazolecarboxylic acid → HCID 20432379, compound

HRID 2412486Notes

Reaction equation

HRID 2412486 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]([OH:9])=O)[CH:3]=1.[NH2:10][CH2:11][CH2:12][C:13]1[N:14]=[C:15]([F:37])[N:16]([C:18]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:17]=1>>[F:37][C:15]1[N:16]([C:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:17]=[C:13]([CH2:12][CH2:11][NH:10][C:7]([C:4]2[CH:3]=[C:2]([CH3:1])[O:6][N:5]=2)=[O:9])[N:14]=1

Participants

3

Reactant 2

HCID 769473-Methyl-5-isoxazolecarboxylic acidHCID 20432352HCID 20432352, compound

Product 1

HCID 20432379HCID 20432379, compound

Procedure

5-Methylisoxazole-3-carboxylic acid and 4-(2-aminoethyl)-2-fluoro-1-triphenylmethylimidazole were reacted by the mixed anhydride procedure described for the starting material of Example 24, to give 2-fluoro-4-[2-(5-methylisoxazole-3-carboxamido)ethyl]-1-triphenylmethylimidazole. It had the following n.m.r. spectrum in d6DMSO: 2.5 (s, 3H); 2.7 (t, 2H); 3.7 (q, 2H); 6.3 (s, 1H); 6.4 (s, 1H); 7.0-7.4 (m, 15H).

Sources & evidence

ORD record
ord-10f7e2508c7d4f608e4f4edcacfde87f
Source dataset
uspto-grants-1985_01
Patent number
US04492692

Reaction notes

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