3-Methyl-5-isoxazolecarboxylic acid → HCID 20432379, compound

Participants

Reaction Steps

5-Methylisoxazole-3-carboxylic acid and 4-(2-aminoethyl)-2-fluoro-1-triphenylmethylimidazole were reacted by the mixed anhydride procedure described for the starting material of Example 24, to give 2-fluoro-4-[2-(5-methylisoxazole-3-carboxamido)ethyl]-1-triphenylmethylimidazole. It had the following n.m.r. spectrum in d6DMSO: 2.5 (s, 3H); 2.7 (t, 2H); 3.7 (q, 2H); 6.3 (s, 1H); 6.4 (s, 1H); 7.0-7.4 (m, 15H).

Provenance & Evidence