Methyl Isocyanate → HCID 20432335, compound

HRID 2412487Notes

Reaction equation

HRID 2412487 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[N:5]=[C:6]([F:28])[N:7]([C:9]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:8]=1.[CH3:29][N:30]=[C:31]=[O:32]>CCOCC>[F:28][C:6]1[N:7]([C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:8]=[C:4]([CH2:3][CH2:2][NH:1][C:31]([NH:30][CH3:29])=[O:32])[N:5]=1

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 20432352HCID 20432352, compound

Product 1

HCID 20432335HCID 20432335, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

4-(2-Aminoethyl)-2-fluoro-1-triphenylmethylimidazole was dissolved in ether, treated with methylisocyanate, and stirred overnight at ambient temperature. Work-up gave 1-[2-(2-fluoro-1-triphenylmethylimidazol-4-yl)ethyl]-3-methylurea, having the following n.m.r. spectrum in CDCl3 : 2.54 (t, 2H); 2.7 (d, 3H); 3.35 (q, 2H); 5.1 (m, 1H); 6.4 (m, 1H); 6.3 (s, 1H); 7.2 (m, 15H).

Sources & evidence

ORD record
ord-632f50d26154422ab809f3c637c0377b
Source dataset
uspto-grants-1985_01
Patent number
US04492692

Reaction notes

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