HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → 4-(2-Carbamoylethyl)-2-fluoro-1-triphenylmethylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 4-(2-Cyanoethyl)-2-fluoro-1-triphenylmethylimidazole | HCID 20432316 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-(2-Carbamoylethyl)-2-fluoro-1-triphenylmethylimidazole | HCID 20432437 | — |
Reaction Steps
4-(2-Cyanoethyl)-2-fluoro-1-triphenylmethylimidazole was dissolved in acetone and treated with aqueous KOH. Hydrogen peroxide was added in portions over seven days at ambient temperature. Extractive work-up and trituration with ether gave 4-(2-carbamoylethyl)-2-fluoro-1-triphenylmethylimidazole, having the following n.m.r. spectrum in CDCl3 : 2.58 (m, 4H); 5.3 (br s, 1H; 6.0 (br s, 1H); 6.26 (s, 1H); 7.0-7.35 (m, 15H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04492692 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-103d1995014b4b73a67231c6d8044ba6 |
| Source note | uspto-grants-1985_01 |