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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2412491Generated: November 1, 2026

4-Methylmorpholine → 2-Fluoro-4-(3-isobutoxycarbonylaminopropyl)-1-triphenylmethylimidazole

https://huagongshe.com/reaction/2412491

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethylmorpholineHCID 7972—
ReactantIsobutyl chloroformateHCID 62365—
Reactant4-(3-Aminopropyl)-2-fluoro-1-triphenylmethylimidazoleHCID 20432314—
SolventTetrahydrofuranHCID 8028—
Product2-Fluoro-4-(3-isobutoxycarbonylaminopropyl)-1-triphenylmethylimidazoleHCID 20432321—

Reaction Steps

4-(3-Aminopropyl)-2-fluoro-1-triphenylmethylimidazole was dissolved in THF and treated with N-methylmorpholine and isobutylchloroformate. Extractive work-up followed by chromatography gave 2-fluoro-4-(3-isobutoxycarbonylaminopropyl)-1-triphenylmethylimidazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04492692
Source datasetuspto-grants-1985_01
ORD IDord-b5ec0d427276430daad4ebb55f4ba67e
Source noteuspto-grants-1985_01