4-Methylmorpholine → 2-Fluoro-4-(3-isobutoxycarbonylaminopropyl)-1-triphenylmethylimidazole

HRID 2412491Notes

Reaction equation

HRID 2412491 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][C:5]1[N:6]=[C:7]([F:29])[N:8]([C:10]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:9]=1.CN1CCOCC1.[CH2:37]([O:41][C:42](Cl)=[O:43])[CH:38]([CH3:40])[CH3:39]>C1COCC1>[F:29][C:7]1[N:8]([C:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:9]=[C:5]([CH2:4][CH2:3][CH2:2][NH:1][C:42]([O:41][CH2:37][CH:38]([CH3:40])[CH3:39])=[O:43])[N:6]=1

Participants

5

Reactant 3

HCID 79724-MethylmorpholineHCID 62365Isobutyl chloroformateHCID 204323144-(3-Aminopropyl)-2-fluoro-1-triphenylmethylimidazole

Product 1

HCID 204323212-Fluoro-4-(3-isobutoxycarbonylaminopropyl)-1-triphenylmethylimidazole

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4-(3-Aminopropyl)-2-fluoro-1-triphenylmethylimidazole was dissolved in THF and treated with N-methylmorpholine and isobutylchloroformate. Extractive work-up followed by chromatography gave 2-fluoro-4-(3-isobutoxycarbonylaminopropyl)-1-triphenylmethylimidazole.

Sources & evidence

ORD record
ord-b5ec0d427276430daad4ebb55f4ba67e
Source dataset
uspto-grants-1985_01
Patent number
US04492692

Reaction notes

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