Methanesulfonyl chloride → 2-Fluoro-4-(3-methanesulphonyloxypropyl)-1-triphenylmethylimidazole

HRID 2412497Notes

Reaction equation

HRID 2412497 reaction equation
[F:1][C:2]1[N:3]([C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:4]=[C:5]([CH2:7][CH2:8][CH2:9][OH:10])[N:6]=1.[CH3:30][S:31](Cl)(=[O:33])=[O:32]>N1C=CC=CC=1>[F:1][C:2]1[N:3]([C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:4]=[C:5]([CH2:7][CH2:8][CH2:9][O:10][S:31]([CH3:30])(=[O:33])=[O:32])[N:6]=1

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 204324552-Fluoro-4-(3-hydroxypropyl)-1-triphenylmethylimidazole

Product 1

HCID 204324122-Fluoro-4-(3-methanesulphonyloxypropyl)-1-triphenylmethylimidazole

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 2-fluoro-4-(3-hydroxypropyl)-1-triphenylmethylimidazole in pyridine was treated with methanesulphonyl chloride. Work-up as for the starting material of Example 9 gave 2-fluoro-4-(3-methanesulphonyloxypropyl)-1-triphenylmethylimidazole, having the following n.m.r. spectrum in CDCl3 : 2.03 (m, 2H); 2.52 (t, 2H); 2.94 (s, 3H); 4.21 (t, 2H); 6.27 (s, 1H); 7.0-7.5 (m, 15H).

Sources & evidence

ORD record
ord-412d75584da947db975e71ab95485a35
Source dataset
uspto-grants-1985_01
Patent number
US04492692

Reaction notes

Loading…