HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → 2-Fluoro-4-(3-methanesulphonyloxypropyl)-1-triphenylmethylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 2-Fluoro-4-(3-hydroxypropyl)-1-triphenylmethylimidazole | HCID 20432455 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-Fluoro-4-(3-methanesulphonyloxypropyl)-1-triphenylmethylimidazole | HCID 20432412 | — |
Reaction Steps
A solution of 2-fluoro-4-(3-hydroxypropyl)-1-triphenylmethylimidazole in pyridine was treated with methanesulphonyl chloride. Work-up as for the starting material of Example 9 gave 2-fluoro-4-(3-methanesulphonyloxypropyl)-1-triphenylmethylimidazole, having the following n.m.r. spectrum in CDCl3 : 2.03 (m, 2H); 2.52 (t, 2H); 2.94 (s, 3H); 4.21 (t, 2H); 6.27 (s, 1H); 7.0-7.5 (m, 15H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04492692 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-412d75584da947db975e71ab95485a35 |
| Source note | uspto-grants-1985_01 |