Pyridine → HCID 54539218, compound

HRID 2412504Notes

Reaction equation

HRID 2412504 reaction equation
[F:1][C:2]1[N:3]([C:12]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:4]=[C:5](/[CH:7]=[CH:8]/[C:9](=O)[CH3:10])[N:6]=1.Cl.[CH3:32][O:33][NH2:34].N1C=CC=CC=1>CCO>[F:1][C:2]1[N:3]([C:12]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:4]=[C:5]([CH:7]=[CH:8][C:9](=[N:34][O:33][CH3:32])[CH3:10])[N:6]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 521874O-Methylhydroxylamine hydrochlorideHCID 20432326HCID 20432326, compound

Product 1

HCID 54539218HCID 54539218, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Examples 55 and 56: E-2-Fluoro-4-(3-oxobut-1-enyl)-1-triphenylmethylimidazole in EtOH was treated with O-methylhydroxylamine hydrochloride and pyridine for 18 hours. Solvent was evaporated and 2-fluoro-4-(3-methoxyiminobut-1-enyl)-1-triphenylmethylimidazole isolated by crystallisation as a 3:1 mixture of isomers. The major Z, E-isomer had the following n.m.r. in CDCl3 : 1.96 (s, 3H); 3.9 (s, 3H); 6.48 (d, 1H); 6.6 (s, 1H); 7.04-7.4 (m, 16H).

Workup

  1. customSolvent was evaporated

Sources & evidence

ORD record
ord-05515f1491034a25ae49be3c24b60765
Source dataset
uspto-grants-1985_01
Patent number
US04492692

Reaction notes

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