Sodium Cyanide → 4-(1-Aminocyanomethyl)-2-fluoro-1-triphenylmethylimidazole

HRID 2412507Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2412507
[NH4+:1].[Cl-].[C-:3]#[N:4].[Na+].[F:6][C:7]1[N:8]([C:14]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:9]=[C:10]([CH:12]=O)[N:11]=1>C1COCC1.CCO>[NH2:1][CH:12]([C:3]#[N:4])[C:10]1[N:11]=[C:7]([F:6])[N:8]([C:14]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:9]=1

Komponenten

6

Edukt 3

HCID 8929Sodium CyanideHCID 25517Ammonium ChlorideHCID 537790282-Fluoro-1-trityl-1H-imidazole-4-carbaldehyde

Produkt 1

HCID 204324254-(1-Aminocyanomethyl)-2-fluoro-1-triphenylmethylimidazole

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

An aqueous solution of NH4Cl and NaCN was added to a solution of 2-fluoro-4-formyl-1-triphenylmethylimidazole in THF and EtOH. After stirring 2 hours at 20° and 5 minutes at 60°, the solution was evaporated and triturated with ether, to give 4-(1-aminocyanomethyl)-2-fluoro-1-triphenylmethylimidazole having the following n.m.r. in CDCl3 : 5.37 (s, 1H); 6.73 (s, 1H); 7.04-7.45 (m, 15H).

Aufarbeitung

  1. customthe solution was evaporated
  2. customtriturated with ether

Quellen und Nachweise

ORD-Eintrag
ord-22af673febe541eabf4ae2fe98c73a1b
Quelldatensatz
uspto-grants-1985_01
Patentnummer
US04492692

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