HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Cyanide → 4-(1-Aminocyanomethyl)-2-fluoro-1-triphenylmethylimidazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Cyanide | HCID 8929 | — |
| Edukt | Ammonium Chloride | HCID 25517 | — |
| Edukt | 2-Fluoro-1-trityl-1H-imidazole-4-carbaldehyde | HCID 53779028 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 4-(1-Aminocyanomethyl)-2-fluoro-1-triphenylmethylimidazole | HCID 20432425 | — |
Reaktionsschritte
An aqueous solution of NH4Cl and NaCN was added to a solution of 2-fluoro-4-formyl-1-triphenylmethylimidazole in THF and EtOH. After stirring 2 hours at 20° and 5 minutes at 60°, the solution was evaporated and triturated with ether, to give 4-(1-aminocyanomethyl)-2-fluoro-1-triphenylmethylimidazole having the following n.m.r. in CDCl3 : 5.37 (s, 1H); 6.73 (s, 1H); 7.04-7.45 (m, 15H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04492692 |
| Quelldatensatz | uspto-grants-1985_01 |
| ORD ID | ord-22af673febe541eabf4ae2fe98c73a1b |
| Quellennotiz | uspto-grants-1985_01 |