反应详情

Reaction of 2-fluoro-1-triphenylmethylimidazole with n-butyl lithium at -75° followed by treatment with phenylisocyanate gave 2-fluoro-4-phenylcarbamoyl-1-triphenylmethylimidazole, n.m.r. in CDCl3 : 7.0-7.5 (m, 19H); 7.6 (d, 2H); 8.6 (s, 1H). Reaction of this product with toluene-p-sulphonic acid in DMF at 85° for 15 minutes gave 2-fluoro-4-phenylcarbamoylimidazole, n.m.r. in CDCl3 : 6.9-8.0 (m, 6H); 9.6 (s, 1H).