HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl isocyanate → 2-Fluoro-4-phenylcarbamoyl-1-triphenylmethylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | 2-Fluoro-1-trityl-1H-imidazole | HCID 20432454 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 2-Fluoro-4-phenylcarbamoyl-1-triphenylmethylimidazole | HCID 20432432 | — |
Reaction Steps
Reaction of 2-fluoro-1-triphenylmethylimidazole with n-butyl lithium at -75° followed by treatment with phenylisocyanate gave 2-fluoro-4-phenylcarbamoyl-1-triphenylmethylimidazole, n.m.r. in CDCl3 : 7.0-7.5 (m, 19H); 7.6 (d, 2H); 8.6 (s, 1H). Reaction of this product with toluene-p-sulphonic acid in DMF at 85° for 15 minutes gave 2-fluoro-4-phenylcarbamoylimidazole, n.m.r. in CDCl3 : 6.9-8.0 (m, 6H); 9.6 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04492692 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-3a03abae24b643eaac40171be917a124 |
| Source note | uspto-grants-1985_01 |