Butanoic acid, 4-chloro-, 1,1-dimethylethyl ester → 1-(3-t-Butoxycarbonylpropyl)-2-fluoroimidazole

HRID 2412517Notes

Reaction equation

HRID 2412517 reaction equation
[F:1][C:2]1[NH:3][CH:4]=[CH:5][N:6]=1.[C:7]([O:11][C:12](=[O:17])[CH2:13][CH2:14][CH2:15]Cl)([CH3:10])([CH3:9])[CH3:8]>>[C:7]([O:11][C:12]([CH2:13][CH2:14][CH2:15][N:3]1[CH:4]=[CH:5][N:6]=[C:2]1[F:1])=[O:17])([CH3:10])([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 527695Butanoic acid, 4-chloro-, 1,1-dimethylethyl esterHCID 5595422-Fluoro-1H-imidazole

Product 1

HCID 204323111-(3-t-Butoxycarbonylpropyl)-2-fluoroimidazole

Procedure

2-Fluoroimidazole was alkylated with t-butyl-4-chlorobutyrate, using the same procedure as that for the starting material of Example 74, to give 1-(3-t-butoxycarbonylpropyl)-2-fluoroimidazole.

Sources & evidence

ORD record
ord-83eb0b47c00549c18137d0c7ec7078f6
Source dataset
uspto-grants-1985_01
Patent number
US04492692

Reaction notes

Loading…