HCID 20432342, compound → HCID 20432399, compound

HRID 2412520Notes

Reaction equation

HRID 2412520 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]([F:27])[N:6]([C:8]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:7]=1.[N+:28]([CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])#[C-:29].CC(C)([O-])C.[K+]>C1COCC1>[CH2:34]([O:33][C:31]([CH:30]([N+:28]#[C-:29])[CH2:2][C:3]1[N:4]=[C:5]([F:27])[N:6]([C:8]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:7]=1)=[O:32])[CH3:35]

Participants

4

Reactant 2

HCID 20432342HCID 20432342, compoundHCID 86739866HCID 86739866, compound

Product 1

HCID 20432399HCID 20432399, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Reaction of 4-chloromethyl-2-fluoro-1-triphenylmethylimidazole with ethyl isocyanoacetate/potassium t-butoxide in THF followed by chromatography on silica gel gave 4-(2-ethoxycarbonyl-2-isocyanoethyl)-2-fluoro-1-triphenylmethylimidazole having the following n.m.r. in CDCl3 : 1.24 (t, 2H); 2.7-3.17 (d, 2H); 4.18 (q, 1H); 4.5 (dd, 1H); 6.4 (s, 1H); 7.0-7.4 (m, 15H).

Sources & evidence

ORD record
ord-079386eb3ef048ce875de3112c27b5c1
Source dataset
uspto-grants-1985_01
Patent number
US04492692

Reaction notes

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