Methyl Isocyanate → HCID 13370464, compound

HRID 2412532Notes

Reaction equation

HRID 2412532 reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:11])([CH3:10])[C:8]#[CH:9])[O:4][N:3]=1.[CH3:12][N:13]=[C:14]=[O:15]>O1CCCC1>[CH3:12][NH:13][C:14]([NH:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:11])([CH3:10])[C:8]#[CH:9])[O:4][N:3]=1)=[O:15]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 13370463HCID 13370463, compound

Product 1

HCID 13370464HCID 13370464, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 7.5 g of 3C and 5 ml of methyl isocyanate in 50 ml of tetrahydrofuran was heated at 50°-60° C. for two days. The solvent was evaporated under reduced pressure and the residue was chromatographed over silica gel, using as eluent a 1:4:20 v:v:v mixture of tetrahydrofuran, ethyl acetate and hexane, to give 1-methyl-3-(5-(1,1-dimethyl-2-propyn-1-yl)-1,2-oxazol-3-yl)urea (3D), as a white crystalline solid, m.p.: 99°-100° C.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was chromatographed over silica gel
  3. additionv:v mixture of tetrahydrofuran, ethyl acetate and hexane

Sources & evidence

ORD record
ord-2dff8a149e3b447984fc47489d7ef96f
Source dataset
uspto-grants-1985_01
Patent number
US04493728

Reaction notes

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