Sodium Hydroxide → HCID 3062237, compound

HRID 2412552Notes

Reaction equation

HRID 2412552 reaction equation
N1C2[C:4](=[CH:5]C=CC=2)[C:3]([CH2:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=C1.[OH-].[Na+].[C:19]1([NH2:30])[C:24](F)=[C:23](F)[C:22](F)=[C:21](N)[C:20]=1F.[ClH:31].Cl>[Cl-].C([N+](CC)(CC)CC1C=CC=CC=1)C.C(Cl)(Cl)Cl.O>[Cl:31][C:4]1[CH:5]=[N:30][C:19]2[C:20]([C:3]=1[CH2:10][CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)=[CH:21][CH:22]=[CH:23][CH:24]=2

Participants

7

Reactant 3

HCID 14798Sodium HydroxideHCID 190261H-Indole, 3-(4-piperidinylmethyl)- (9CI)HCID 149026Tetrafluoro-m-phenylenediamine dihydrochloride

Product 1

HCID 3062237HCID 3062237, compound

Reagents, catalysts & solvents 3

HCID 66133Benzyl triethylammonium chlorideCatalystHCID 962WaterSolventHCID 6212ChloroformSolvent

Procedure

The operation is as in Example 1, but starting from 13.4 g of 4-(3-indolyl-methyl)-piperidine and 0.54 g of triethylbenzylammonium chloride in 130 ml of chloroform and 19.5 g of sodium hydroxide in solution in 39 ml of water. 4.2 g of 3-chloro-4-[(4-piperidyl)-methyl]-quinoline are finally obtained in the form of the dihydrochloride melting above 260° C.

Sources & evidence

ORD record
ord-b92e81efc7c7407ab4c6b1541f8273b5
Source dataset
uspto-grants-1985_01
Patent number
US04493838

Reaction notes

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