HCID 86651778, compound → HCID 66717306, compound

HRID 241259Notes

Reaction equation

HRID 241259 reaction equation
C([O:5][C:6](=[O:45])[CH2:7][N:8](C(OC(C)(C)C)=O)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]([S:29]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=2)(=[O:31])=[O:30])[NH:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[N:25]=[CH:26][S:27][CH:28]=3)=[CH:20][CH:19]=2)[N:10]=1)(C)(C)C.C(OC(=O)CN(C(OC(C)(C)C)=O)C1C=CC=C(C(S(C2C=CC=CN=2)(=O)=O)NCC2C=CC(C3SC=CN=3)=CC=2)N=1)(C)(C)C>>[N:33]1[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=1[S:29]([CH:15]([NH:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[N:25]=[CH:26][S:27][CH:28]=2)=[CH:20][CH:19]=1)[C:11]1[N:10]=[C:9]([NH:8][CH2:7][C:6]([OH:45])=[O:5])[CH:14]=[CH:13][CH:12]=1)(=[O:31])=[O:30]

Participants

3

Reactant 2

HCID 86651778HCID 86651778, compoundHCID 86651779HCID 86651779, compound

Product 1

HCID 66717306HCID 66717306, compoundYield 53.4%

Procedure

Reaction and post-treatment were carried out in the same manner as in Example 3-(b) except for using tert-butyl[tert-butoxycarbonyl(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-4-yl)benzyl]aminomethyl}pyridin-2-yl)amino]acetate (230 mg, 0.353 mmol) obtained in Example 16-(a) in place of tert-butyl[tert-butoxycarbonyl(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-yl)amino]acetate to afford the title compound (93.5 mg) as a white solid. (Yield: 53%)

Workup

  1. customReaction

Sources & evidence

ORD record
ord-3e152130df6b49a4adcc4d63ecc0eaf5
Source dataset
uspto-grants-2014_02
Patent number
US08648097B2

Reaction notes

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