HRID241259

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)CN(C(=O)OC(C)(C)C)c1cccc(C(NCc2ccc(-c3cscn3)cc2)S(=O)(=O)c2ccccn2)n1

HCID86651778

未命名化合物

结构：CC(C)(C)OC(=O)CN(C(=O)OC(C)(C)C)c1cccc(C(NCc2ccc(-c3nccs3)cc2)S(=O)(=O)c2ccccn2)n1

HCID86651779

未命名化合物

PRODUCTS

生成物

结构：O=C(O)CNc1cccc(C(NCc2ccc(-c3cscn3)cc2)S(=O)(=O)c2ccccn2)n1

HCID66717306

未命名化合物

收率 53.4%

PROCEDURE

实验过程

Reaction and post-treatment were carried out in the same manner as in Example 3-(b) except for using tert-butyl[tert-butoxycarbonyl(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-4-yl)benzyl]aminomethyl}pyridin-2-yl)amino]acetate (230 mg, 0.353 mmol) obtained in Example 16-(a) in place of tert-butyl[tert-butoxycarbonyl(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-yl)amino]acetate to afford the title compound (93.5 mg) as a white solid. (Yield: 53%)

WORKUP

后处理

customReaction

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3e152130df6b49a4adcc4d63ecc0eaf5
来源数据集: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08648097B2
来源说明: uspto-grants-2014_02

反应 SMILES

C([O:5][C:6](=[O:45])[CH2:7][N:8](C(OC(C)(C)C)=O)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]([S:29]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=2)(=[O:31])=[O:30])[NH:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[N:25]=[CH:26][S:27][CH:28]=3)=[CH:20][CH:19]=2)[N:10]=1)(C)(C)C.C(OC(=O)CN(C(OC(C)(C)C)=O)C1C=CC=C(C(S(C2C=CC=CN=2)(=O)=O)NCC2C=CC(C3SC=CN=3)=CC=2)N=1)(C)(C)C>>[N:33]1[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=1[S:29]([CH:15]([NH:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[N:25]=[CH:26][S:27][CH:28]=2)=[CH:20][CH:19]=1)[C:11]1[N:10]=[C:9]([NH:8][CH2:7][C:6]([OH:45])=[O:5])[CH:14]=[CH:13][CH:12]=1)(=[O:31])=[O:30]