HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylamine → 4-(n-Hexadecanamido)-3-methylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylamine | HCID 7622 | — |
| Reactant | Palmitoyl chloride | HCID 8206 | — |
| Reactant | 4-Amino-3-methylbenzoic acid | HCID 75598 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(n-Hexadecanamido)-3-methylbenzoic acid | HCID 12800009 | 27% |
Reaction Steps
A stirred solution of 4-amino-3-methylbenzoic acid (30.2 g), in dry dimethylformamide (300 ml), containing tributylamine (55 ml) was treated with n-hexadecanoyl chloride (61.0 g) in a similar manner to that described in Example 1(i) to give 4-(n-hexadecanamido)-3-methylbenzoic acid (21 g), in the form of white needles, m.p. 194°-196° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04493843 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-692326a004f34935b07a4554c09541b2 |
| Source note | uspto-grants-1985_01 |