Hydrochloric Acid → HCID 24839536, compound

HRID 2412599Notes

Reaction equation

HRID 2412599 reaction equation
[CH2:1]([CH:16]1[CH2:24][C:23]2[C:18](=[CH:19][C:20]([C:25]([OH:27])=[O:26])=[CH:21][CH:22]=2)[NH:17]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].[ClH:28].C(OCC)C>C(O)C>[ClH:28].[CH2:1]([CH:16]1[CH2:24][C:23]2[C:18](=[CH:19][C:20]([C:25]([OH:27])=[O:26])=[CH:21][CH:22]=2)[NH:17]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 12799964HCID 12799964, compound

Product 1

HCID 24839536HCID 24839536, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of (RS)-2-(n-pentadecyl)indoline-6-carboxylic acid (3.0 g) in ethanol (30 ml), was treated with a saturated solution of hydrogen chloride gas in ethanol (50 ml of strength 34% w/v). Anhydrous diethyl ether was then added to the mixture until a solid separated. The solid was collected and was washed with diethyl ether (2×100 ml) to give (RS)-2-(n-pentadecyl)indoline-6-carboxylic acid hydrochloride (2.7 g), in the form of a colourless solid, m.p. 230°-240° C. (with decomposition).

Workup

  1. customseparated
  2. customThe solid was collected
  3. washwas washed with diethyl ether (2×100 ml)

Sources & evidence

ORD record
ord-d031699c132a45739560faa398de9cf7
Source dataset
uspto-grants-1985_01
Patent number
US04493843

Reaction notes

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