反应详情

A solution of 2-(n-undecyl)indole-6-carboxylic acid (15.0 g) in methanol (200 ml) containing aqueous hydrochloric acid (10 ml of strength 36.5% w/v) was refluxed for 8 hours. The solution was concentrated in vacuo to about one half of its volume, diluted with diethyl ether (300 ml) and washed with water. The solution was dried over magnesium sulphate, then evaporated in vacuo and the residue was recrystallised from methanol to give methyl 2-(n-undecyl)indole-6-carboxylate (10.5 g), in the form of an off-white powder, m.p. 84°-86° C.

1. temperaturewas refluxed for 8 hours
2. concentrationThe solution was concentrated in vacuo to about one half of its volume
3. additiondiluted with diethyl ether (300 ml)
4. washwashed with water
5. dry with materialThe solution was dried over magnesium sulphate
6. customevaporated in vacuo
7. customthe residue was recrystallised from methanol