反应详情

A solution of 2-(n-pentadecyl)indole-5-carboxylic acid (17.4 g) in n-butanol (100 ml) containing aqueous hydrochloric acid (10 ml of strength 36.5% w/v) was heated in a steam bath for 18 hours. The solution was concentrated in vacuo to about one half of its volume and the residue was dissolved in diethyl ether. The ethereal solution was washed with water (2×50 ml) and was dried over magnesium sulphate. Evaporation of the solvent in vacuo gave a solid, which was recrystallised from light petroleum ether (b.p. 40°-60° C.) and then from methanol to give n-butyl 2-(n-pentadecyl)indole-5-carboxylate (12.2 g), in the form of a white powder, m.p. 79°-80° C.

1. temperaturewas heated in a steam bath for 18 hours
2. concentrationThe solution was concentrated in vacuo to about one half of its volume
3. dissolutionthe residue was dissolved in diethyl ether
4. washThe ethereal solution was washed with water (2×50 ml)
5. dry with materialwas dried over magnesium sulphate
6. customEvaporation of the solvent in vacuo
7. customgave a solid, which
8. customwas recrystallised from light petroleum ether (b.p. 40°-60° C.)