反应详情

A solution of 2-(n-undecyl)indole-6-carboxylic acid (15.0 g) in n-butanol (100 ml) containing aqueous hydrochloric acid (10 ml, of strength 36.5% w/v) was heated on a steam bath for 16 hours. The solution was concentrated in vacuo to approximately half of its volume and the solid which crystallised on cooling was collected and washed with light petroleum ether (b.p. 40°-60° C.) to give n-butyl 2-(n-undecyl)-indole-6-carboxylate (11.3 g), in the form of white crystals, m.p. 73°-76° C.

1. temperaturewas heated on a steam bath for 16 hours
2. concentrationThe solution was concentrated in vacuo to approximately half of its volume
3. customthe solid which crystallised
4. temperatureon cooling
5. customwas collected
6. washwashed with light petroleum ether (b.p. 40°-60° C.)