Sodium Hydroxide → HCID 23682492, compound

HRID 2412612Notes

Reaction equation

HRID 2412612 reaction equation
[CH2:1]([C:16]1[NH:17][C:18]2[C:23]([CH:24]=1)=[CH:22][CH:21]=[C:20]([C:25]([OH:27])=[O:26])[CH:19]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].[OH-].[Na+:29]>C(O)C.O>[CH2:1]([C:16]1[NH:17][C:18]2[C:23]([CH:24]=1)=[CH:22][CH:21]=[C:20]([C:25]([O-:27])=[O:26])[CH:19]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].[Na+:29]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 12797216HCID 12797216, compound

Product 1

HCID 23682492HCID 23682492, compoundYield 93.2%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 2-(n-pentadecyl)indole-6-carboxylic acid (15.0 g) in hot ethanol (100 ml) was treated with a solution of sodium hydroxide (2.0 g) in water (50 ml), and a white precipitate was obtained. The precipitate was recrystallised from aqueous ethanol (1:1) (300 ml) to give sodium 2-(n-pentadecyl)-indole-6-carboxylate (14.8 g), in the form of white crystals, m.p. greater than 340° C.

Workup

  1. customa white precipitate was obtained
  2. customThe precipitate was recrystallised from aqueous ethanol (1:1) (300 ml)

Sources & evidence

ORD record
ord-4534768c28be4667a5be91c24c743914
Source dataset
uspto-grants-1985_01
Patent number
US04493843

Reaction notes

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