反应详情

A stirred mixture of 4-(n-hexadecanamido)-3-methylbenzoic acid (4 g), potassium tert-butoxide (4 g) and diethylaniline (10 ml) was refluxed for 3.5 hours. The fraction boiling at less than 200° C. during the reaction was collected. The reaction mixture was left to cool to room temperature and was then acidified with 10% w/v hydrochloric acid. The solid was filtered off, dried and recrystallized from toluene to give 2-(n-pentadecyl)indole-5-carboxylic acid (2.7 g), m.p. 108°-110° C.

1. temperaturewas refluxed for 3.5 hours
2. customThe fraction boiling at less than 200° C. during the reaction was collected
3. waitThe reaction mixture was left
4. filtrationThe solid was filtered off
5. customdried
6. customrecrystallized from toluene