反应详情

n-Dodecanoyl chloride (9.9 g) was added dropwise to a stirred suspension of (2-amino-4-methoxycarbonylbenzyl)triphenylphosphonium bromide (22.9 g) in dry dimethylformamide (225 ml) and stirring continued for 3 hours. The resulting solution was evaporated in vacuo to give an orangebrown oil which on treatment with water gave a solid. The solid was collected, washed with water, dried, washed with diethyl ether and collected to give [4-methoxycarbonyl-2-(n-dodecanamido)benzyl]triphenylphosphonium bromide (22.9 g) in the form of a pale yellow solid, m.p. 142°-145° C.

1. customThe resulting solution was evaporated in vacuo
2. customto give an orangebrown oil which on treatment with water
3. customgave a solid
4. customThe solid was collected
5. washwashed with water
6. customdried
7. washwashed with diethyl ether
8. customcollected