Hydrochloric Acid → HCID 24839539, compound

HRID 2412643Notes

Reaction equation

HRID 2412643 reaction equation
[ClH:1].[CH2:2]([CH:13]1[CH2:21][C:20]2[C:19]([C:22]([OH:24])=[O:23])=[CH:18][CH:17]=[CH:16][C:15]=2[NH:14]1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].C(OCC)C>C(O)C.CC(C)=O>[ClH:1].[CH2:2]([CH:13]1[CH2:21][C:20]2[C:19]([C:22]([OH:24])=[O:23])=[CH:18][CH:17]=[CH:16][C:15]=2[NH:14]1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 12799978HCID 12799978, compound

Product 1

HCID 24839539HCID 24839539, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 702EthanolSolvent2×

Procedure

A solution of hydrogen chloride in ethanol (37% w/v, 20 ml) was added to a solution of (RS)-2-(n-undecyl)indoline-4-carboxylic acid (15.0 g) in ethanol (80 ml) and acetone (170 ml). After 30 seconds, anhydrous diethyl ether (800 ml) was added and the product was collected and washed with fresh anhydrous diethyl ether to give (RS)-2-(n-undecyl)indoline-4-carboxylic acid hydrochloride (14.2 g) in the form of a white powder, m.p. 220°-230° C. (with decomposition).

Workup

  1. customthe product was collected
  2. washwashed with fresh anhydrous diethyl ether

Sources & evidence

ORD record
ord-a0d149fe45e446c5aef402a69878069e
Source dataset
uspto-grants-1985_01
Patent number
US04493843

Reaction notes

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