HCID 86651783, compound → HCID 66717452, compound

HRID 241265Notes

Reaction equation

C([O:5][C:6](=[O:46])[CH2:7][N:8](C(OC(C)(C)C)=O)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([C:33]3[S:34][C:35]([Cl:38])=[CH:36][N:37]=3)=[CH:29][CH:28]=2)[NH:16][S:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)(=[O:19])=[O:18])[N:10]=1)(C)(C)C.C(OC(=O)CN(C(OC(C)(C)C)=O)C1C=CC=C(C(CC2C=CC(C3SC(C)=CN=3)=CC=2)NS(C2C=CC=CN=2)(=O)=O)N=1)(C)(C)C>>[Cl:38][C:35]1[S:34][C:33]([C:30]2[CH:29]=[CH:28][C:27]([CH2:26][CH:15]([NH:16][S:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=3)(=[O:19])=[O:18])[C:11]3[N:10]=[C:9]([NH:8][CH2:7][C:6]([OH:46])=[O:5])[CH:14]=[CH:13][CH:12]=3)=[CH:32][CH:31]=2)=[N:37][CH:36]=1

Participants

Reactant 2

HCID 86651783HCID 86651783, compound

HCID 86651784HCID 86651784, compound

Product 1

HCID 66717452HCID 66717452, compoundYield 66%

Procedure

Reaction and post-treatment were carried out in the same manner as in Example 22-(d) except for using tert-butyl[tert-butoxycarbonyl(6-{[4-(5-chlorothiazol-2-yl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-yl)amino]acetate (265 mg, 0.386 mmol) obtained in Example 24-(a) in place of tert-butyl[tert-butoxycarbonyl(6-{[4-(5-methylthiazol-2-yl)benzyl] (pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-yl)-amino]acetate to afford the title compound (135 mg) as a slightly brown solid. (Yield: 66%)

Workup

customReaction

Sources & evidence

ORD record: ord-39539939dc334c7a882e713941e9080f
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08648097B2

Reaction notes

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