2-(Propan-2-yl)-1,4,5,6-tetrahydropyrimidine → 2-(Propan-2-yl)pyrimidine

HRID 2412650Notes

Reaction equation

HRID 2412650 reaction equation
[CH:1]([C:4]1[NH:5][CH2:6][CH2:7][CH2:8][N:9]=1)([CH3:3])[CH3:2].[H][H].[H][H].N#N>N1C=CC=CC=1.[Pt]>[CH:1]([C:4]1[N:9]=[CH:8][CH:7]=[CH:6][N:5]=1)([CH3:3])[CH3:2]

Participants

6

Reactant 3

HCID 128683772-(Propan-2-yl)-1,4,5,6-tetrahydropyrimidineHCID 178418361HCID 178418361, compoundHCID 178514468HCID 178514468, compound

Product 1

HCID 123439882-(Propan-2-yl)pyrimidineYield 73%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 1049PyridineSolvent

Procedure

A solution of 70 g of 2-isopropyl-1, 4, 5, 6-tetrahydropyrimidine in 100 ml of pyridine was fed at about 1 ml/min to a column 1"×20" containing about 50 g of 0.5 percent platinum on α-alumina at 300° to 325° C. while sweeping out the column with a mixture of nitrogen and hydrogen. The catalyst had been activated by passing a 2:1 H2 /N2 stream over the bed for two hours. The effluent was distilled giving 2-isopropylpyrimidine at 152° to 155° C. The yield was 73 percent.

Workup

  1. customfor two hours
  2. distillationThe effluent was distilled

Sources & evidence

ORD record
ord-142d7d6a82464681b8f988d39d9d874b
Source dataset
uspto-grants-1985_01
Patent number
US04493929

Reaction notes

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