HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(5-Bromothiophen-2-yl)ethan-1-amine--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Reactant | Phosphoramidic acid, ion(2-) | HCID 211207 | — |
| Reactant | diethyl N-[2-(5-bromothien-2-yl)-ethyl]-phosphoramidate | HCID 13740538 | — |
| Product | 2-(5-Bromothiophen-2-yl)ethan-1-amine--hydrogen chloride (1/1) | HCID 13131559 | 60% |
Reaction Steps
A solution containing 3.42 g. (0.01 mol) diethyl N-[2-(5-bromothien-2-yl)-ethyl]-phosphoramidate in 50 ml. diisopropyl ether saturated with hydrogen chloride is stirred overnight at ambient temperature. The crystals formed are filtered off and washed with diisopropyl ether. After drying, there is obtained 1.45 g. (yield: 60%, referred to the phosphoramidate used) of the desired product in the form of silverygrey flakes; m.p. 220° C. (decomposition)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04493931 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-27c98e0b85574fae9430a1f6c1868a03 |
| Source note | uspto-grants-1985_01 |