反应详情

A solution containing 3.42 g. (0.01 mol) diethyl N-[2-(5-bromothien-2-yl)-ethyl]-phosphoramidate in 50 ml. diisopropyl ether saturated with hydrogen chloride is stirred overnight at ambient temperature. The crystals formed are filtered off and washed with diisopropyl ether. After drying, there is obtained 1.45 g. (yield: 60%, referred to the phosphoramidate used) of the desired product in the form of silverygrey flakes; m.p. 220° C. (decomposition)

1. additionA solution containing 3.42 g
2. customThe crystals formed
3. filtrationare filtered off
4. washwashed with diisopropyl ether
5. customAfter drying
6. customthere is obtained 1.45 g