Hydrochloric Acid → 4-Pyridineethanamine

HRID 2412660Notes

Reaction equation

HRID 2412660 reaction equation
[C:1]1([CH2:7][CH2:8][NH:9]P(=O)(OCC)OCC)[CH:6]=[CH:5]C=[CH:3][CH:2]=1.Cl.[NH2:19]CP(=O)(OCC)OCC>>[N:9]1[CH:5]=[CH:6][C:1]([CH2:2][CH2:3][NH2:19])=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 93764Diethyl phenethylphosphoramidateHCID 1596920Diethyl (aminomethyl)phosphonate

Product 1

HCID 832754-PyridineethanamineYield 47.5%

Procedure

Treatment of the phosphoramidate obtained in stage (d) with an aqueous solution of hydrochloric acid, under the conditions described in Example 1, gives, after rendering the mixture basic, 5.6 g. (yield: 47.5%, referred to the diethyl aminomethylphosphonate) of the desired amine in the form of a yellow oil which turns brown in air.

Workup

  1. customgives

Sources & evidence

ORD record
ord-c3e59bb9216f48acada1682da5874e5d
Source dataset
uspto-grants-1985_01
Patent number
US04493931

Reaction notes

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