HRID2412788

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24387

Phosphorous trichloride

Cl3P

结构：COc1ccc(OCC(=O)OCC2=C(C(=O)OC(c3ccccc3)c3ccccc3)N3C(=O)C(NC(=O)Cc4ccccc4)[C@H]3S(=O)C2)cc1

HCID70490327

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(OCC(=O)OCC2=C(C(=O)OC(c3ccccc3)c3ccccc3)N3C(=O)C(NC(=O)Cc4ccccc4)[C@H]3SC2)cc1

HCID70490587

未命名化合物

收率 90.5%

PROCEDURE

实验过程

Benzhydryl 7-(2-phenylacetamido)-3-[2-(4-methoxyphenoxy)acetoxymethyl]-3-cephem-4-carboxylate-1-oxide (6.9 g.) and phosphorus trichloride (2.7 g.) were reacted according to a similar manner to that of Preparation 30 (3) to give benzhydryl 7-(2-phenylacetamido)-3-[2-(4-methoxyphenoxy)acetoxymethyl]-3-cephem-4-carboxylate (6.1 g.).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a71bad37fa6643d7bde25edd7b1fffc8
来源数据集: uspto-grants-1985_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04493833
来源说明: uspto-grants-1985_01

反应 SMILES

[C:1]1([CH2:7][C:8]([NH:10][CH:11]2[C:49](=[O:50])[N:13]3[C:14]([C:33]([O:35][CH:36]([C:43]4[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=4)[C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=4)=[O:34])=[C:15]([CH2:19][O:20][C:21](=[O:32])[CH2:22][O:23][C:24]4[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=4)[CH2:16][S:17](=O)[C@H:12]23)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)Cl>>[C:1]1([CH2:7][C:8]([NH:10][CH:11]2[C:49](=[O:50])[N:13]3[C:14]([C:33]([O:35][CH:36]([C:43]4[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=4)[C:37]4[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=4)=[O:34])=[C:15]([CH2:19][O:20][C:21](=[O:32])[CH2:22][O:23][C:24]4[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1