HRID2412789

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1049

Pyridine

C5H5N

HCID24819

Phosphorus pentachloride

Cl5P

结构：COc1ccc(OCC(=O)OCC2=C(C(=O)OC(c3ccccc3)c3ccccc3)N3C(=O)C(NC(=O)Cc4ccccc4)[C@H]3SC2)cc1

HCID70490587

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(OCC(=O)OCC2=C(C(=O)OC(c3ccccc3)c3ccccc3)N3C(=O)C(N)[C@H]3SC2)cc1

HCID70491124

未命名化合物

收率 92.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Benzhydryl 7-(2-phenylacetamido)-3-[2-(4-methoxyphenoxy)acetoxymethyl]-3-cephem-4-carboxylate (6.0 g.), phosphorus pentachloride (5.65 g.), pyridine (2.2 g.) and methanol (7.3 ml.) were reacted according to a similar manner to that of Preparation 30 (4) to give benzhydryl 7-amino-3-[2-(4-methoxyphenoxy)acetoxymethyl]-3-cephem-4-carboxylate (4.6 g.).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3d3655707a7743b289134c6ab6c73194
来源数据集: uspto-grants-1985_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04493833
来源说明: uspto-grants-1985_01

反应 SMILES

C1(CC([NH:10][CH:11]2[C:48](=[O:49])[N:13]3[C:14]([C:32]([O:34][CH:35]([C:42]4[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=4)[C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=4)=[O:33])=[C:15]([CH2:18][O:19][C:20](=[O:31])[CH2:21][O:22][C:23]4[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=4)[CH2:16][S:17][C@H:12]23)=O)C=CC=CC=1.P(Cl)(Cl)(Cl)(Cl)Cl.N1C=CC=CC=1>CO>[NH2:10][CH:11]1[C:48](=[O:49])[N:13]2[C:14]([C:32]([O:34][CH:35]([C:42]3[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=3)[C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=3)=[O:33])=[C:15]([CH2:18][O:19][C:20](=[O:31])[CH2:21][O:22][C:23]3[CH:24]=[CH:25][C:26]([O:29][CH3:30])=[CH:27][CH:28]=3)[CH2:16][S:17][C@H:12]12