Pyridine → HCID 70491124, compound

HRID 2412789Notes

Reaction equation

HRID 2412789 reaction equation
C1(CC([NH:10][CH:11]2[C:48](=[O:49])[N:13]3[C:14]([C:32]([O:34][CH:35]([C:42]4[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=4)[C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=4)=[O:33])=[C:15]([CH2:18][O:19][C:20](=[O:31])[CH2:21][O:22][C:23]4[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=4)[CH2:16][S:17][C@H:12]23)=O)C=CC=CC=1.P(Cl)(Cl)(Cl)(Cl)Cl.N1C=CC=CC=1>CO>[NH2:10][CH:11]1[C:48](=[O:49])[N:13]2[C:14]([C:32]([O:34][CH:35]([C:42]3[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=3)[C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=3)=[O:33])=[C:15]([CH2:18][O:19][C:20](=[O:31])[CH2:21][O:22][C:23]3[CH:24]=[CH:25][C:26]([O:29][CH3:30])=[CH:27][CH:28]=3)[CH2:16][S:17][C@H:12]12

Participants

5

Reactant 3

HCID 1049PyridineHCID 24819Phosphorus pentachlorideHCID 70490587HCID 70490587, compound

Product 1

HCID 70491124HCID 70491124, compoundYield 92.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Benzhydryl 7-(2-phenylacetamido)-3-[2-(4-methoxyphenoxy)acetoxymethyl]-3-cephem-4-carboxylate (6.0 g.), phosphorus pentachloride (5.65 g.), pyridine (2.2 g.) and methanol (7.3 ml.) were reacted according to a similar manner to that of Preparation 30 (4) to give benzhydryl 7-amino-3-[2-(4-methoxyphenoxy)acetoxymethyl]-3-cephem-4-carboxylate (4.6 g.).

Sources & evidence

ORD record
ord-3d3655707a7743b289134c6ab6c73194
Source dataset
uspto-grants-1985_01
Patent number
US04493833

Reaction notes

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