反应详情

A solution of 14.8 g of the sulfonamide from Example 1 and 10 ml of 48% hydrobromic acid in 100 ml of methanol was heated at 40°-45° for 16 hours, concentrated, and neutralized wth aqueous sodium bicarbonate. The solid was filtered, washed with ice-water, and air-dried to afford 6.0 g of product, m.p. 186°-190°. NMR(CDCl3 /DMSO-d6)δ: 7.5 (m, 7), 8.1 (m, 2), 8.6 (d, 1). 1R(Nujol) 3300, 3260 cm-1. m/e M+ 234.

1. concentrationconcentrated
2. filtrationThe solid was filtered
3. washwashed with ice-water
4. customair-dried